CONCENTRATION OF BOUND PANTOTHENIC ACID

Assay and distribution of bound forms of pantothenic acid.

The distribution of CoA (I), pantetheine (2, 3), and pantothenic acid (4) among a variety of natural materials is well established. However, until now, the relative amounts of these compounds present in any one substance has not been determined. Also, data on the distribution of P-pantothenic1 acid and P-pantetheine, both of which are intermediates in the biosynthesis of CoA (5), is rather meag...

Microbic Decomposition of Pantothenic Acid.

The metabolism of pantothenic acid.

The formulation of this pathway was based on: (a) the finding that cysteine supplies the sulfur-containing moiety of CoA (3,4); (b) the activities of pantetheine and pantothenylcysteine as growth factors for Acetobacter suboxydans (4-6) and Lactobacillus helveticus (7); (c) the presence of enzymes in these two organisms and also in Lactobacillus bulgur&s which decarboxylate pantothenylcysteine ...

Synthesis and properties of pantothenic acid monophosphates.

Although it appears most probable that coenzyme A is a phosphate derivative of pantothenic acid (2), little information is available as to the position or nature of the phosphate linkage in the molecule. It became of interest in this connection to examine the properties of simple phosphate derivatives of pantothenic acid, and for this purpose efforts were directed toward the preparation of the ...

The Liberation of Pantothenic Acid from Coenzyme

It was reported previously that coenzyme A contained pantothenic acid bound in such a manner as to make it unavailable in microbiological tests (1). A liberation of p;alanine on acid hydrolysis indicated early the presence of pantothenic acid, which was confirmed by chick assay (2). While the chick assay for pantothenic acid and the p-alanine assay by the yeast growth test yielded equivalent am...